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Problem to solve?

Placenta accreta spectrum (PAS) defines abnormally invasive placental implantation, which are at high risk of inducing severe obstetrical complications, such life-threatening hemorrhage during delivery. This condition affects 1/533-1/2510 deliveries1-4 and its incidence is associated with the increase of uterine surgery, mainly the cesarean section and has increased 10-fold over the past 50 years5.

World wide?

The same increase in cesarean section rates and in PAS cases is observed in world wide. Therefore the recognition of this rare condition by the healthcare providers is mandatory to develop an efficient management policy reducing effectively the maternal and neonatal morbidity and mortality.

Solution available?

Improvement of prenatal diagnosis of PAS and referral of the patient to a expertise center in order to organize the delivery in the best conditions are mandatory to improve the outcome6, 7. That policy is far to be applied routinely for this moment.

Diseases registries play an important part in improving health outcomes8. They also reduce the costs of health care. Through the use of such registries, health-care providers can compare, identify and adopt best practices for patients. Since in most countries, governments support registries of rare diseases financially, we believe that it is time to develop an PAS registry in order to improve obstetrical healthcare.

Urgency of this work?/ Why this consortium?

Large cohort studies regarding the diagnosis and the management of PAS are lacking. Further, the incidence of this condition increases as recent data show. For example, in the USA are expected for 2020, 4504 placenta accretas and 130 maternal deaths per year, additionally9. Via IS-PAS, the world can benefit now from a network of at least 13 expertise centers all over Europe/World able to improve knowledge and management and to inform and sensitize the healthcare decision makers.



On behalf of EW/IS-AIP/IS-PAS the following paper has been recently published: 


Diagn Interv Imaging. 2019 Jun;100(6):319-325. doi: 10.1016/j.diii.2019.02.004. Epub 2019 Mar 8.
A proposal for standardized magnetic resonance imaging (MRI) descriptors of abnormally invasive placenta (AIP) - From the International Society for AIP.
Am J Obstet Gynecol. 2019 Jun;220(6):511-526. doi: 10.1016/j.ajog.2019.02.054. Epub 2019 Mar 5.
Evidence-based guidelines for the management of abnormally invasive placenta: recommendations from the International Society for Abnormally Invasive Placenta.
Ultrasound Obstet Gynecol. 2016 Mar;47(3):271-5. doi: 10.1002/uog.14952.
Proposal for standardized ultrasound descriptors of abnormally invasive placenta (AIP).

Pubmed link



With the contribution of EW-AIP the following paper has been recently published: 

Ultrasound Obstet Gynecol. 2016 Mar;47(3):276-8. doi: 10.1002/uog.15810.
Pro forma for ultrasound reporting in suspected abnormally invasive placenta (AIP): an international consensus.

Pubmed link 



1. Angstmann T, Gard G, Harrington T, Ward E, Thomson A, Giles W. Surgical managment of placenta accreta: a cohort series and suggested approach. Am J Obstet Gynecol 2010; 202:38 e1-9  

2. Miller DA, Chollet JA, Goodwin TM. Clinicla risk factors for placenta-previa accreta- Am J Obstet Gynecol 1997; 177:210-4

3. Timmermans S, van Hof AC, Duvekot JJ. Conservative management of abnormally invasive placentation. Obstet Gynecol Surv 2007;62:529-39.

4. Resnik R, Lockwood C, Levine D. Diagnosis and management of placenta accreta. In:UpToDate. Waltham, MA, 2011: UpToDate, Basow, DS (Ed), 2011.

5. Khong TY. The pathology of placenta accreta, a worldwide epidemic. J Clin Pathol 2008;61:1243-6.

6. Tikkanen M, Paavonen J, Loukavaara M, Stefanovic V. Antenatal diagnosis of placenta accreta leads to reduced blood loss. Acta Obstet Gynecol Scand 2011;90:1140-6.

7. Befort MA. Placenta accreta. Am J Obstet Gynecol 2010;203:430-9.

9. Solheim KN, Esakoff TF, Litle SE, Cheng YW, Soarks TN, Caughey AB. The effect of cesarean delivery rates on the future incidence of placenta previa, placenta accreta, and maternal mortality. J Matern Fetal Neona 2011.


Special Issue on AIP in Acta Obstetricia et Gynecologica Scandinavica April 2013!